VarMod
Variant Modeller

Modelling functional effects of non-synonymous variants


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Submission Details
Email: m.n.wass@kent.ac.uk
Unique Submission identifier: vm53679eaef042c
Description: RAS
Uniprot Accession: P01112
Query Seq: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQ
YMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIP
YIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS


Analysis Summary
The table below shows the machine learning VarMod prediction and a summary of the features used to make the predictionThey are colour coded to indicate how relevant each feature is likely to be when considering if the variant affects the protein functionThe sections below provide detailed information relating to sequence conservation, ligand binding sites and protein-protein interactions.The structural data can be used to investigate the structural environment of the variants and consider how this mayhave an effect on protein function.
VariantVarMod ProbabilityInterfaceBinding siteConservationsizeChargeFunc grp
G13R0.8190.0000.0000.763
T58I0.7640.0000.0000.767
Q61K0.3780.0000.1470.688
K117R0.6920.0000.0000.633


Sequence View - Conservation Data
1102030405060
SequenceMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
Conservation
Binding site
Interface
Variants
61708090100110120
SequenceQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
Conservation
Binding site
Interface
Variants
121130140150160170180
SequenceAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
Conservation
Binding site
Interface
Variants
181
SequenceCMSCKCVLS
Conservation
Binding site
Interface
Variants


Structural Analysis

Structural Templates

The details of the models generated for the protein are listed below.These include the structural templates used, the range of the protein sequence includedand the variants present within each of the models
ModelTemplateSequence RangeTemplate probabilityVariants present
12ce2_X 1-166 100Q61K, K117R, G13R, T58IDownload model
In this section view the structural model and the ligand binding and interface sites.The jmol viewer displays the model of the protein with these regions mapped onto the structure. The control panel on the right can be used to modify the display of the protein, and the residues - variants, binding sites and interfaces

Structural Model


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Display Controls

Protein Model

Variants

Predicted Binding Site Residues

Protein-Protein interface Residues

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Interaction Data

Below is a list interaction partners in uniprot with the query protein. Models of the complex of these interactions are available.Click the relevant identifier to view the model in relation to the variants. They will be displayed in a separate window
Q9NZL6P21359P11233O15211
P04049Q9NS23P15056P10398
P20936P01112Q12967Q07889
Q8WWW0Q07890Q9P212P48736